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Some patients with dementia may experience delayed-onset PTSD

The review describes three cases where post-traumatic stress disorder (PTSD) symptoms are experienced by patients suffering with dementia long after the original traumatic event. Considering PTSD in individuals with dementia is important because PTSD is usually associated with working-age adults and is infrequently diagnosed in the elderly. In the early stages of dementia, recognising early life trauma may enable patients to access psychological therapy prior to significant cognitive decline. In patients with more advanced dementias, an awareness of earlier trauma exposure can help clinicians differentiate between delayed PTSD and BPSD in patients suffering with emotional and behavioural disturbances. "Every patient with dementia has a unique narrative, which if captured in the earlier stages of the disease, enables clinicians and their families to understand the origin of their distress. Therefore, it is important to look for a history of previous trauma in patients with B...
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Natural plant compound may reduce mental effects of aging, more evidence shows

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Salk scientists discover advantages of antioxidant fisetin in mouse mannequin of untimely growing old, Alzheimer's illness. Pamela Maher is pictured. Credit score: Salk Institute Salk scientists have discovered additional proof pure compound in strawberries reduces cognitive deficits and irritation related to growing old in mice. The work, which appeared within the  Journals of Gerontology Collection A  in June 2017, builds on the group's earlier analysis into the antioxidant fisetin, discovering it might assist deal with age-related psychological decline and situations like Alzheimer's or stroke. "Firms have put fisetin into varied well being merchandise however there hasn't been sufficient severe testing of the compound," says Pamela Maher, a senior workers scientist in Salk's Mobile Neurobiology Laboratory and senior creator of the paper. "Primarily based on our ongoing work, we predict fisetin may be u...
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Sleep, Alzheimer's link explained

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Analysis from Washington College College of Medication in St. Louis, Radboud College Medical Centre within the Netherlands, and Stanford College reveals that disrupting only one evening of sleep in wholesome, middle-aged adults causes a rise in a mind protein related to Alzheimer's illness. Additional, per week of poor sleep results in a rise in one other mind protein that has been linked to mind injury in Alzheimer's and different neurological illnesses. Proven are mind waves throughout slow-wave sleep, measured as a research participant slept. Credit score: Yo-El Ju A very good evening's sleep refreshes physique and thoughts, however a poor evening's sleep can just do the alternative. A research from Washington College College of Medication in St. Louis, Radboud College Medical Centre within the Netherlands, and Stanford College has proven that disrupting only one evening of sleep in wholesome, middle-aged adults causes a r...
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New data network for Huntington's disease research

Scientists around the world are working to find effective therapies for Huntington's disease. While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes. In research, this complexity has resulted in huge and diverse sets of data which in turn pose considerable challenges to researchers in collating, analysing and cross-referencing varied data sources. An international team of researchers, bioinformaticians and biostatisticians has developed the first freely available data network for scientists researching this debilitating and fatal condition, called HDNetDB. In a paper published in  Scientific Reports , the HDNetDB team outlines the challenges facing those investigating Huntington's disease, explains how HDNetDB works and illustrates its effectiveness by discovering potential drug targets, which might help to prevent the neuronal cell death observed i...
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New imaging technique able to watch molecular dynamics of neurodegenerative diseases

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A brand new method that gives each chemical composition and molecular orientation data at subsecond timescales might reveal new details about what happens on the molecular stage as illnesses corresponding to Alzheimer's and a number of sclerosis progress. Credit score: Sophie Brasselet, Institut Fresnel, CNRS, Aix Marseille Université Researchers have developed a quick and sensible molecular -scale imaging method that would let scientists view never-before-seen dynamics of organic processes concerned in neurodegenerative illnesses corresponding to Alzheimer's illness and a number of sclerosis. The brand new method reveals a pattern's chemical make-up in addition to the orientation of molecules making up that pattern, data that can be utilized to know how molecules are behaving. What's extra, it acquires this data in mere seconds, considerably sooner than the minutes required by different methods. The sooner velocity means will ...
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Source of cell-specific change in Alzheimer's disease

Using an extremely precise method of isolating cells called "laser capture microdissection," researchers looked at three specific cell types -- microglia , astrocytes and neurons -- in the brain tissue of individuals with a pathological diagnosis of Alzheimer's disease, and compared them to brain samples from healthy individuals and those with Parkinson's disease. Following sequencing of each of these cell types, the ASU-TGen led team found that altered ANK1 expression originates in microglia, a type of immune cell found in the brain and central nervous system, according to the study published today in the scientific journal  PLOS ONE . "Although previous genetic and epigenetic-wide association studies had shown a significant association between ANK1 and AD, they were unable to identify the class of cells that may be responsible for such association because of the use of brain homogenates. Here, we provide evidence that microglia are the source of the previ...
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Drug combined with care program better at reducing Alzheimer's symptoms than drug alone

These are the findings from a randomized trial developed at NYU Langone Medical Center and presented Sunday July 16 at the Alzheimer's Association International Conference 2017 in London. "Alzheimer's and dementia clinicians have known for some time that medication alone is not enough to stop disease progression," says research principal investigator Barry Reisberg, MD, professor of psychiatry and director of the Zachary and Elizabeth M. Fisher Alzheimer Disease Education and Resources program at NYU Langone. "Our new research shows that a comprehensive, patient-centered care program brings significant benefits in daily activities, which are important to individuals with Alzheimer's and those who care for and about them." Reisberg was the first author of a 2003  New England Journal of Medicine  paper that was used in the U.S. Food and Drug Administration's approval of memantine, making it the first treatment for the later stages of Alzheimer...
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